The Storehouse, which tells visitors the story of the drinks company, has had 13 million people through its doors since it opened in 2006.
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It was named among winners in the prestigious World Travel Awards ceremony in Sardinia.
Failte Ireland chief executive Shaun Quinn hailed the win as a great boost for Irish tourism.
"In what is shaping up to be a record year for the tourism sector, this win confirms that we must be getting something right," he said.
"When you consider that this was an open worldwide public vote and that the Storehouse beat back competition from the Acropolis, Buckingham Palace, the Colosseum and the Eiffel Tower, you know that the Storehouse must be delivering what visitors want - truly authentic and memorable experiences."
He added: "I'd like to congratulate managing director Paul Carty and all the team at the Guinness Storehouse for their impressive performance."